In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. Intestinal wall is made up of tight-fitting single layer of epithelial cell where drug is transported by active transport or passive transport. The major challenge in the oral drug delivery of poorly permeable drug is their transport across intestine. drug’s solubility and permeability across intestine. Two factors govern the total oral absorption of drug i.e. Thus, BCS class 4 Cefixime can be treated as bcs class 2 by increasing its solubility instead of permeability as evident by ex-vivo and in vivo study. In vivo study was carried out using Pluronic sd in male Wister rats (n=6) and which showed enhanced absorption of Cefixime with AUC 1.9 times greater than of the aqueous plain Cefixime suspension. Solid dispersion prepared with Pluronic found to show marked increment in solubility and dissolution as well as in ex-vivo permeation study. Prepared formulations were also evaluated for % drug permeation using non-everted rat intestinal sac method which showed that Pluronic was not involved in permeability enhancement of Cefixime. Physicochemical characterisation was done using saturated solubility studies, in vitro dissolution, ATR, DSC, SEM, and XRD study.
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Pluronic and complexing agent beta cyclodextrin.Ĭomparative study was carried out using Pluronic as solid dispersion and beta cyclodextrin as inclusion complexation in different drug to polymer ratios through physical mix, kneading, solvent evaporation and spray drying technique.
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Cefixime using P-glycoprotein inhibitor hydrophile i.e. Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine.